| abstract |
Provided is a single-chain circular RNA having a sustained or slow-releasing RNA interference effect, wherein the single-chain circular RNA comprises a sense strand sequence, an antisense strand sequence complementary to the sense strand sequence, identical or different two loop sequences between the sense strand and the antisense strand, connecting both strands, wherein the sense strand and the antisense strand are paired to form a stem, and wherein each, of the two loops is 6 to 9 nucleotides in length. The RNAs can be used to suppress gene activity in vivo and show an extended effect. |