abstract |
A lactam-cyclized peptide of formula (I) where R1, X1, X3, X7-X10 and R2 are as defined in the claims. The peptide is cyclized by an amide bond between the side chains of the residues X1 and X7. The peptide is a CXCR4 antagonist and can be used for the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis and HIV infection. |