http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-579997-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2008-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e13f5514fa42ebfb804c3bcc5c58a4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d9b15130435699d68f321f81e21cde1 |
| publicationDate | 2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-579997-A |
| titleOfInvention | PROCESS FOR PREPARATION OF N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
| abstract | Disclosed is a process for the preparation of a salt of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine (Erlotinib) comprising: reacting a 4-halo-6,7-bis(2-methoxyethoxy)quinazoline with 3-aminophenyl acetylene (or an acid salt thereof under acidic conditions) in a solvent, the solvent being selected from the group consisting water, dimethyl carbonate, special denatured spirit (SPDS), acetonitrile, acetone, ethyl acetate, isopropyl alcohol and mixtures thereof. The process optionally further comprises converting the acid salt of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine to N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine. The process can be carried out under ambient conditions. |
| priorityDate | 2007-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.