| abstract |
A modified membrane type serine protease (MTSP-1) protease comprising a mutation at one or more of the amino acid residues in the S1, S2, S3 or S4 region of a wild-type MTSP-1. In particular the mutations occur at the amino acid residues 99, 171, 174, 180, 190, 191, 192, 215, 217, 218 or 226 by chymotrypsin numbering. The modifications result in altered cleavage activity and/or specificity of the protease. (62) Divided Out of 539242 |