| abstract |
Disclosed is a method for immunizing a dog against infection caused by Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona, comprising administering to said dog a therapeutically effective amount of a combination vaccine consisting of a Leptospira cell preparation of Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae, and Leptospira pomona, wherein the amount of each Leptospira strain in the vaccine is in the range of about 100-3500 nephelometric units per vaccine dose, and an attenuated strain of canine distemper (CD) virus, an attenuated strain of canine adenovirus type 2 (CAV-2), an attenuated strain of canine parainfluenza (CPI) virus, and an attenuated strain of canine parvovirus (CPV), wherein the amount of each of said attenuated strains of CD virus, CAV-2, CPI virus, and CPV in said vaccine is in the range of 102 to 109 TCID50 per dose, and optionally a carrier. |