| abstract |
Disclosed is a sterile, stable aqueous pharmaceutical composition comprising: a solution of deoxygenated water and sodium sulfide nonahydrate; wherein the sodium sulfide nonahydrate produces Na2S, H2S and HS-; wherein the concentration of H2S is in the range of 1.0 mg/mL to 4.0 mg/mL; wherein the solution is adjusted to a pH in the range of 7.5 to 8.5 by adding HCl to the solution; wherein the solution has an osmolarity in the range of 250-330 mOsmol/L; wherein the solution further comprises sulphide oxidation products selected from the group consisting of polysulfide, sulphite, sulphate and thiosulphate; wherein the oxidation products comprise sulfate in the range of (0%-1.0%), sulfite in the range of (0%-1.0%), polysulfide in the range of (0%-1%) or thiosulfate in the range of (0% - 1.0%); wherein the solution is isotonic or near isotonic; and wherein the solution is stable for at least four months. |