| abstract |
Disclosed is a dihydroxysuccinamide compound of formula (I) wherein the substituents is as disclosed in the specification. Examples of compounds of formula (I) include: (2R,3R)-N-(1-aminoisoquinolin-6-yl)-2,3-dihydroxy-N'-p-tolylsuccinamide, (2R,3R)-N-(2-amino-3H-benzimidazol-5-yl)-2,3-dihydroxy-N'-p-tolylsuccinamide, (2R,3R)-N-(2-amino-3H-benzimidazol-5-yl)-N'-(4-cyclohexylphenyl)-2,3-dihydroxysuccinamide. Also disclosed is a process for preparing a compound of formula (I); a medicament comprising a compound of formula (I) and the use of a compound of formula (I) in the production of a medicament for the prophylaxis, secondary prevention and therapy of all those diseases which accompany thrombosis, embolisms, hypercoagulability or fibrotic changes. |