abstract |
Disclosed are imidazo[4,5-b]pyrazine derivatives represented by general formulae (I) and (II), or pharmaceutically acceptable salts thereof, wherein R1 is alkenyl or alkynyl, R4 is hydrogen and R2 is 3-pentyl, 4-heptyl, 4-methyl-1-morpholinopentan-2-yl, isobutyl, cyclohexyl, cyclopropyl, sec-butyl, tert-butyl, isopropyl, 1-hydroxybutan-2-yl, tetrahydro-2H-pyran-4-yl, 1-methoxybutan-2-yl, 1-aminobutan-2-yl, or1-morpholinobutan-2-yl. Also disclosed is the use of the compounds of formula (I) or (II) for treating neuromuscular disease. |