| abstract |
Disclosed are (R)-2-amino-2-methyl-alkan-1-ols as represented by the general formula (1a) wherein R3 represents a straight chain alkyl group having 1 to 3 carbon atoms, X represents an oxygen atom or a sulfur atom , and n denotes 2 or 3; or a pharmaceutically acceptable salt or hydrate thereof. Of particular importance are the compounds (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenoxy)phenyl]-2-methylpentan-1-ol, (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, (R)-2-amino-4-[2-chloro-4-(3-trifluoromethylphenoxy)phenyl]-2-methylbutan-1-ol, (R)-2-amino-4-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylbutan-1-ol and (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-propylpentan-1-ol and pharmaceutically acceptable salts or hydrates thereof. Further disclosed is a pharmaceutical which comprises an amino alcohol derivative, or a pharmaceutically acceptable salt or hydrate thereof as defined above as an active ingredient for the prevention or treatment of rejection reactions in organ transplants or bone marrow transplants, or for use as an immunosuppressive agent. |