| abstract |
Disclosed are statin derivatives of the general formula A-Y-X; wherein A is a statin; Y is a succinic acid moiety; and X is 4-thiocarbamoyl-phenyloxy group. Of particular importance are compounds where A is selected from atorvastatin, cilastatin, dermostatin, fluvastatin, lovastatin, mevastatin, pravastatin sodium, and simvastatin; such as succinic acid 2-{ 2-[8-(2,2-dimethyl-butyryloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yI]-ethyl} -6-oxo-tetrahydro-pyran-4-yl ester 4-thiocarbamoyl-phenyl ester. |