| abstract |
Disclosed is a phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one represented by formula (I) including salts and both Rand S enantiomeric forms and racemic mixtures thereof wherein A1 is H, Br, Cl, nitro, or trifluoromethyl; R is methyl or H, R2 is defined in the specification, R3 is H, Br, Cl, nitro, or trifluromethyl; R5 is alkyl, phenyl, phenoxy, hydroxyphenyl, Br, F or CI; R6 is H, Br, CI, F, -methoxy, or ethoxy; X is NH for treating an immune disorder, a hyperproliferative disorder, and a chronic inflammatory condition, a graft versus host disease, rheumatoid arthritis, and systemic lupus erythematosusm, cancer, neoplasm, lymphoma, myeloma or leukemia, asthma and psoriasis. |