http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-573223-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7254887bc4324c447a6a7cfda1e6b29c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-209 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2077 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 |
| filingDate | 2007-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a50f7e635802bd871907d9346cf3786 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43aa1377c1f0df144944649acda4f993 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17bd1545c9c87d1dbed52315f553e068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7889d7863ce89299d243b8e92395546 |
| publicationDate | 2012-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-573223-A |
| titleOfInvention | Pharmaceutical composition comprising amlodipine and losartan |
| abstract | A use of a composition for the manufacture of a medicament for preventing or treating cardiovascular disorders, said composition comprising amlodipine ((RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate) or a pharmaceutically acceptable salt thereof, losartan ((2-butyl-4-chloro-1-{ [2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl} -1H-imidazol-5-yl)methanol) or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients, wherein amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof in the composition are physically separated from each other, wherein the composition is prepared by a method comprising the steps of granulating amlodipine or a pharmaceutically acceptable salt thereof to obtain an amlodipine granule part, and mixing the amlodipine granule part with a mixture part comprising losartan or a pharmaceutically acceptable salt thereof. Also disclosed is a method of preparing a compound comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof, which comprises the steps of: a) wet-granulating and drying a mixture of amlodipine or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients to obtain an amlodipine granule part; and b) mixing the amlodipine granule part obtained in step a) with a mixture part comprising losartan or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients. Further disclosed is a composition made by this method. |
| priorityDate | 2006-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.