| abstract |
Disclosed is a solid composition comprising SAMe and/or NADH or its salts in association with calcium oxide and optionally pharmaceutically acceptable excipients. A process for preparing the above composition is also disclosed, the process comprising the steps of: a) mixing of the SAMe and/or NADH and/or their salts with calcium oxide and pharmaceutically acceptable excipients, b) precompression and subsequent granulation of the mixture obtained in stage a), c) mixing of the granulate obtained in stage b) with pharmaceutically acceptable excipients, d) compression of the mixture obtained in stage c), with the optional addition of sweeteners and/or flavourings, e) optional coating of the solid composition obtained in stage d) with hydrogenated fatty acids, f) optional aqueous phase film-coating of the solid composition obtained in stage e). |