| abstract |
Disclosed is a composition for inhibiting adhesion comprising a water-soluble and temperature-sensitive polymer showing a sol-gel phase transition dependant upon temperature, wherein the polymer is a temperature-sensitive multiblock copolymer where two or more identical or different block copolymers selected from polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO) block copolymer and polyethylene oxide (PEO)-polybutylene oxide (PBO)-polyethylene oxide (PEO) block copolymer are linked by a dicarboxyl group linker and wherein the polymer is subjected to phase-transition from a sol state to a gel state by the body temperature, stably coated within tissues, thereby functions as a barrier inhibiting adhesion, and as time lapses, degraded into a low molecular weight surfactant and a biodegradable single-molecular substance, whereby the degraded products exhibit secondary adhesion inhibiting effects. |