http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-570482-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ed9a8826e874e45a3047da75b569965 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-24 |
| filingDate | 2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a4e9ddeb6fef2855814bc65d46759dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5a5c19172478a5229ea3efb721f8061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_134f062e4484a93e00e9bb3000f26372 |
| publicationDate | 2010-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-570482-A |
| titleOfInvention | Process for preparing 1-halo-2,7-naphthyridinyl derivatives |
| abstract | Disclosed is a process for the preparation of a 1-halo-2,7-naphthyridine compound of formula (I): wherein X is Cl or Br; which process comprises the following steps: (i) reaction of a 3-cyano-4-methylpyridine derivative of formula (A) with a compound of formula (II) in the presence of an N,N-dimethylformamide dialkylacetal; to give an enamine derivative of formula (III) wherein R2 and R3 independently represent hydrogen, Cl or Br; and Cy represents a N-linked 4 to 6 membered heterocyclic ring in which m is 1 or 2; n is 1 or 2; Y represents -CHR-, -NR1-, -O- or -S(O)x-; x is zero, 1 or 2; each R independently represents hydrogen or alkyl; and R1 represents hydrogen or alkyl; (ii) cyclisation of the enamine of formula (III), followed, as necessary, by removal of all Cl or Br atoms, to obtain the compound of formula (IV), and (iii) reaction of the compound of formula (IV) with a halogenating agent, to obtain a compound of formula (I). |
| priorityDate | 2006-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.