| abstract |
Disclosed is a method for assessing the risk of development of, or likely progression of, age-related macular degeneration in a human subject, the method comprising the steps of determining whether the subject carries one or more polymorphisms or one or more allelic variants selected from: a) A or G at rs641153 of the complement factor B (BF) gene, or R or Q at position 32 of the BF protein; b) A or Tat rs4151667 of the BF gene, or L or H at position 9 of the BF protein; c) G or Tat rs547154 of the C2 gene; and d) C or G at rs9332739 of the C2 gene, or E or D at position 318 of the C2 protein, wherein if the subject does not have at least one of the one or more polymorphisms or al1e1ic variants, the subject is at increased risk for developing age related macular degeneration, wherein the method is not performed on a living human body. |