abstract |
Provided is an anti-CD200 antibody, comprising an altered Fc constant region, wherein the antibody inhibits the interaction between CD200 and CD200R, wherein the Fc constant region has 0 to 20% of the effector function of the corresponding native Fc constant region, and wherein the anti-CD200 antibody comprises specified 6 CDR sequences. The antibody can be used to treat various cancers. |