abstract |
The use of a multivalent Streptococcus pneumoniae vaccine that comprises 7 or more capsular saccharide conjugates from different serotypes for the treatment or prevention of disease caused by S. pneumoniae. The composition comprises a serotype 22F saccharide conjugated to a carrier protein selected from tetanus toxin (TT), diphtheria toxin (DT) CRM197, fragment C of TT, PhtD, PhtDE fusions, detoxified pneumolysin and protein D. The diseases to be treated are otitis media, meningitis, bacteraemia, pneumonia and/or conjunctivitis. The vaccine can also comprise the capsular saccharide conjugates from serotypes 4, 6B, 9V, 14, 18C and 23F. |