| abstract |
Disclosed herein is a 2,8-diazaspirl[4.5]decan-1-one compound of formula III, wherein the substituents are as defined with in the specification, processes for their preparation and compositions comprising said compounds. Such compounds are useful in the treatment of obesity, diabetes, glucose intolerance, insulin resistance, hyperglycemia, atherosclerosis, hypertension, hyperlipidemia, cognitive impairment, dementia, depression, glaucoma, cardiovascular disorders, osteoporosis, inflammation, metabolic syndrome, coronary heart disease, type 2 diabetes, hypercortisolemia, androgen excess, or polycystic ovary syndrome (PCOS). |