| abstract |
Disclosed is a compound of Formula I or a salt, solvate or hydrate thereof e.g. tert-butyl { (1R)-1-[(difluoromethoxy)methyl]-2-[(3,4-difluorobenzyl)amino]-2-oxoethyl} carbamate and (2R)-3-(difluoromethoxy)-N-(4-fluorobenzyl)-2-[(methylsulfonyl)amino] propanamide wherein: A is selected from the group consisting of aryl and heteroaryl ;R1 is a haloalkyl group; R2 is selected from the group consisting of C(O)R6, C(O)OR6, SO2R6 and C(O)NR6R7; R3, R4 and R5 are independently selected from the group consisting of H and alkyl; R6 and R7 are independently selected from the group consisting of H and alkyl for the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders |