abstract |
Disclosed is a compound of formula I or II, or a pharmaceutically acceptable salt thereof, wherein A is a 3-7 membered monocyclic cycloalkyl ring, RAA and RBB together are a substituted pyrrolidinyl ring, the Rx groups may be separate or may together form a ring, and wherein the other substituents are as defined in the specification. Also disclosed is the use of the compound for increasing the number of functional CFTR in a membrane of a cell, and for treating conditions implicated by CFTR in a patient. Also disclosed is a method of producing the compound. |