| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98a32cb57f32db448f5c7df23bd090ed |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-622 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-335 |
| filingDate |
2006-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fd6eac267342486e45435d144c1ef10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d080a37cd31fb50856ff5cb2e7f1723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d5a5cdd51ba8f73683e30ce58e1e8a8 |
| publicationDate |
2010-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-565271-A |
| titleOfInvention |
Bifunctional protein anchors comprising a peptidoglycan binding doman fused to an antigen binding domain |
| abstract |
Disclosed is an antigen-loaded immunogenic carrier complex, comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached non-covalently to said carrier, fused to an antigen binding domain (ABD) capable of binding non-covalently an antigen of interest, wherein said PBD comprises an amino acid sequence selected from the group consisting of (i) a LysM domain; (ii) an amino acid sequence retrieved from a homology search in an amino acid sequence database with a LysM domain in the C-terminus of Lactococcus lactis cell wall hydrolase AcmA (said domain herein also referred to as AcmA LysM domain) wherein said retrieved sequence has at least 70% homology to said AcmA LysM domain; and (iii) a sequence showing at least 70% sequence identity to (i); provided that the PBD is capable of attaching to the cell wall of a Gram-positive microorganism; and wherein at least one antigen of interest is bound to said ABD. Further disclosed are methods of providing said antigen loaded immunogenic complex, pharmaceutical compositions and uses thereof. |
| priorityDate |
2005-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |