| abstract |
Disclosed is a compound including a piperidine and a piperazine as shown in formula (I), or a salt thereof, wherein A is phenyl or pyridine, and the other substituents are as defined in the specification. Also disclosed is the use of the compound to treat conditions mediated by GPR38 receptors, such as gastroesophageal reflux disorders, functional dyspepsia, irritable bowel syndrome, constipation, intestinal pseudo-obstruction, paralytic ileus following surgery or other manipulation, emesis, gastric stasis or hypomotility caused by various diseases such as diabetes and/ or by the administration of other drugs, Crohn's disease, colitis, cachexia associated with advanced diseases such as cancer and/or the treatment thereof, appetite/metabolism related cachexia, and incontinence. Also disclosed is a method to synthesise the compound, and intermediates useful in that method. |