| abstract |
Disclosed is a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is H, optionally substituted C1-6 alkyl, optionally substituted C1-4 alkaryl, optionally substituted C1-4 alkheterocyclyl, or optionally substituted C1-4heterocyclyl, each of R4 and R7 is H, F, C1-6 alkyl, or C1-6 alkoxy, R5 is H, R5AC(NH)NH(CH2)r5 or R5BNHC(S)NH(CH2)r5, r5 is an integer from 0 to 2, R6 is H, R6AC(NH)(CH2)r6 or R6BNHC(S)NH(CH2)r6, r6 is an integer from 0 to 2, and wherein the rest of the substituents are as defined in the specification. Also disclosed is the use of the compound to treat conditions caused by the action of nitric oxide synthase such as migraine headache (with or without aura), chronic tension type headache (CTTH), migraine with allodynia, neuropathic pain, post-stroke pain, chronic headache, chronic pain, acute spinal cord injury, diabetic neuropathy, trigeminal neuralgia, diabetic nephropathy, an inflammatory disease, stroke, reperfusion injury, head trauma, cardiogenic shock, CABG associated neurological damage, HCA, AIDS associated dementia, neurotoxicity, Parkinson's disease, Alzheimer's disease, ALS, Huntington's disease, multiple sclerosis, metamphetamine-induced neurotoxicity, drug addiction, morphine/opioid induced tolerance, dependence, hyperalgesia, or withdrawal, ethanol tolerance, dependence, or withdrawal, epilepsy, anxiety, depression, attention deficit hyperactivity disorder, or psychosis. |