| abstract |
Disclosed is a cyclopropylcyclopentylthiophene derivative of formula (I), or a configurational isomer, salt or solvent thereof, wherein A is an oxadiazole ring, and wherein the other substituents are as described in the specification. Also disclosed is the use of the compound for treating diseases or disorders associated with an activated immune system, such as: rejection of transplanted organs selected from kidney, liver, heart and lung; graft-versus-host diseases brought about by stem cell transplantation; autoimmune syndromes selected from rheumatoid arthritis, multiple sclerosis, psoriasis, psoriatic arthritis, Crohn's disease, and Hashimoto's thyroiditis; and atopic dermatitis. |