| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_857f8336175d4a3144facf2e9ad3998b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-106664 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
| filingDate |
2006-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dc47f02f7ed7fe3eb154f7cb4e2c58e |
| publicationDate |
2011-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-562467-A |
| titleOfInvention |
Hepatitis-B viral variants with reduced susceptibility to nucleoside analogs and uses thereof |
| abstract |
Disclosed is an isolated HBV (Hepatitis B Virus) variant that comprises at least one nucleotide mutation in the DNA polymerase gene at codon position 181, according to the genotype-independent numbering scheme for HBV polymerase, which results in an alanine to serine amino acid substitution, rtA181S. The isolated HBV variant exhibits a decreased sensitivity to the nucleoside analogue Adefovir and/or Lamivudine. Also disclosed is the isolated HBV variant with at least one further nucleotide mutation in the DNA polymerase gene at codon position 204 of the polymerase gene. |
| priorityDate |
2005-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |