| abstract |
Disclosed is a pharmaceutical composition, comprising a therapeutically effective amount of at least one quinazoline tertiary amine having Formula (I) or a salt thereof wherein R1 is chosen from OCH3, OCHF2, and OCH2CH3 and R2 is chosen from CH3, CI, CH2F, and SCH3 and one or more non-ionic surfactants, in particular (2-chloro-quinzolin-4-yl)-(4-methoxy-phenyl)-methyl-amine, (2-fluoromethyl-quinzolin-4-yl)-(4-methoxy-phenyl)-methyl-amine, (4-methoxy-pheny)l-methyl-(2-methyl-quinzolin-4-yl)-amine, (4-difluoromethoxy-phenyl)-(2-methyl-quinzolin-4-yl)-methyl-amine, (2-chloro-quinzolin-4-yl)-(4-ethoxy-phenyl)-methyl-amine, (4-ethoxy-phenyl)-(2-methyl-quinzolin-4-yl)-methyl-amine and (2-methylthio-quinzolin-4-yl)-(4-methoxy-phenyl)-methyl-amine. Also disclosed is a kit comprising said composition, a method of preparing said composition and the use of the composition for the manufacture of a medicament to treat diseases or disorders e.g. cancer. |