| abstract |
Disclosed are pyrrolo-piperidine derivatives as represented by the general formula (I), which are useful for the inhibition of bacterial DNA gyrase and/or topoisomeraseIV, wherein: W is -O-, -N(R6)- or -C(R7)(R8)-; X is a direct bond, -CH2-, -C(O)- or S(O)q; and wherein the piperidine moiety is substituted with at least one R4 substituent; and wherein R4 and the other substituents are as defined herein. Of particular importance is the compound 2-[(3S,4R)-4-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]-3-methoxy-1-piperidyl]-4-[[(1S)-2-methoxy-I-methylethyl]carbamoyl]thiazole-5-carboxylic acid. |