| abstract |
Disclosed are compositions comprising a virus-like particle (VLP) and at least one allergen which is a feline FeI d1 protein comprised of a Fel d1 chain 1 covalently linked to a Fel d1 chain 2, wherein the VLP and allergen are covalently linked through respective attachment sites. Further disclosed are methods for producing the compositions. The compositions induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens. |