| abstract |
Disclosed is the use of carbazole derivatives of general formula (I), in which: X represents >CR1R2 or, when R6 does not represent a hydrogen atom, X can also represent >SO2; Y is >CR1R2; Z is >C=O, >CH2 or a direct bond; R1 is hydrogen atom and R2 is hydrogen, a carboxy group or a hydroxy group; or R1 and R2 together represent an oxo group, an ethylenedioxy group or a hydroxyimino group; R3 is hydrogen or alkyl; R4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R5 is hydrogen, alkyl or halogen; R6 is hydrogen, alkoxy, or a carboxy group; R7 and R8 are independently represented by hydrogen, alkyl or halogen; and pharmaceutically acceptable salts and esters thereof for the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions caused by ischaemic damage to tissues of peripheral organs. Of particular importance are the compounds 7,8-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-3-ol, 5,8-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-3-ol, 8-methoxy-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole 2,2-dioxide and 5,8-dimethyl-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid, |