| abstract |
Disclosed are 1-(b-D-glucopyranosyl)-indole derivatives as represented by the formula (I), wherein R1 is halogen or alkyl; R2 is hydrogen, or halogen, and Ar is selected from an optionally substituted phenyl or thiophenyl moiety. Also disclosed is a pharmaceutical composition comprising a compound as defined above and a pharmaceutically acceptable carrier or diluent, and which may further comprise another antidiabetic agent. Further disclosed is the use of a compound as defined above in the manufacture of a medicament for use in the treatment of disorders selected from diabetes mellitus, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, delayed wound healing, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids, elevated blood levels of glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, diabetic complications, atherosclerosis, and hypertension. |