| abstract |
Provided is a polypeptide comprising human papillomavirus E6 and E7 polypeptides, wherein the E7 polypeptide has mutations at any one or more of the amino acids corresponding to amino acids 24,26 or 91 of a specified polypeptide and the E6 polypeptide has no mutations or has mutations at any one or more of the amino acids corresponding to amino acids 63 or 106 of a specified E7 polypeptide and the mutant polypeptide retains at least approximately 30% of the immunogenicity of an isolated peptide comprising human wild-type papillomavirus E6 and E7. Further provided are corresponding expression vectors, host cells comprising the vector, immunogenic compositions and use of the compositions for the manufacture of medicaments to produce an immune response and to treat cervical cancer. |