http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-556478-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 2006-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_baac6f78cf335df2529b5fc80d4cee66 |
| publicationDate | 2011-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-556478-A |
| titleOfInvention | DR5 antibodies and uses thereof |
| abstract | Provided is an anti-DRS antibody comprising mutations in the heavy and light chain of full-length antibody 16E2, or a fragment thereof, wherein: said antibody or antibody fragment has a greater affinity for DRS than full-length antibody 16E2 and is capable of activating or stimulating apoptosis in cancer cells; and the mutations comprise: (i) a set of heavy chain mutations selected from the group consisting of (i) NS3Q, L102Y; (ii) M34L, N53Q, L102Y; (iii) N53Y, L102Y;(iv) M34L, N53Y, L102Y; (v) G33A, N53Q, L102Y; (vi) M34L, N53Y, L102Y; (vii) G33A, N53Q, L102Y; (viii) G33A, N53Y, L102Y; (ix) T28A, N53Q, L102Y; and (x) T28A, NS3Y, L102Y; and (ii) a set of light chain mutations selected from the group consisting of (i) Q24S, G50K, K51D, H95bY; (ii) Q24S, K51A, D92S, S93Y; and (iii) Q24S, K51A, R91A in the amino acid sequence. The antibodies can be used to treat cancer. |
| priorityDate | 2005-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1083.