| abstract |
Provided is the use of a trefoil factor (TFF) inhibitor compound in the manufacture of a medicament for inhibiting proliferation and/or survival of a tumor or for treating or preventing cancer or a cell proliferation and/or survival disorder in a subject, wherein said compound inhibits the expression of a trefoil factor 1 gene (TFF1) or decreases the activity of a trefoil factor 1 protein, wherein said compound is selected from an antibody composition that binds to at least TFF1 protein, one or more iRNAs or DNAs encoding iRNAs, a peptide antagonist of a TFF1 protein selected from a functional interfering mutant of a TFF of a specified sequence comprising a non- identical amino acid at positions 20, 21, 42, 43, 46 or 58 or a fragment thereof, wherein said antagonist inhibits binding of an endogenous TFF1 to a TFF1 receptor in said cell or inhibits TFF1 dimerization, aggregation or functional activity. Further provided are corresponding nucleic acids and peptide antagonists. |