| abstract |
Disclosed is a compound of formula (I), where R1 is ethyl or isopropyl, and R2 is an optionally substituted alkyl group, and pharmaceutically acceptable salts an esters thereof. The compound is a 5-HT4 receptor partial agonist. Also disclosed in the use of the compound to treat a CNS or peripheral nervous system disorder such as Alzheimer's disease, cognition disorders, irritable bowel syndrome, Parkinson's disease, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorder, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction and respiratory depression. |