abstract |
Provided are 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(S)-hydroxymethyl}-benzoic acid and related compounds which are useful in the treatment of migraine. The compounds are potentiators of mGlu2 receptor and antagonists of the CysLT1 receptor and provide a means to treat disorders associated with glutamate or leukotrienes. |