| abstract |
Disclosed herein are N-(1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl) benzamide derivatives represented by compounds of formula (I) wherein substitutents are as defined in the specification, as well as pharmaceutically acceptable salts, esters, compositions of these compounds together with pharmaceutically acceptable carriers and uses of these compounds. These substituted imidazole compounds are useful as kinesin spindle protein (KSP) inhibitors in the treatment of cancer. |