| abstract |
Disclosed is a natriuretic compound conjugate comprising: a biologically active natriuretic compound wherein the natriuretic compound is a brain natriuretic peptide (BNP) comprising a natriuretic molecule NPR-A binding site that exhibits NPR-A receptor binding activity and comprises a disulfide loop for binding to the NPR-A receptor, at least one modifying moiety conjugation site, wherein the modifying moiety conjugation site comprises at least one lysine amino acid residue of BNP; and at least one modifying moiety attached to said modifying moiety conjugation site of Formula 1A, wherein C is an alkyl moiety of m carbons, m is between 1 and 20, n is between 1 and 25, and X is selected from -C-, -O-, -C(O)-, -OC(O)-, -NH-, -NHC(O)-, and -C(O)NH-. Also disclosed is the use of the natriuretic compound conjugate for treating an excessive level of extracellular fluid. |