| abstract |
Disclosed is a method of screening for a modulator of WRN comprising a) providing a cell that expresses WRN; b) contacting candidate modualtors with said cell under conditions in which the modulator is taken up by the cell; c) measuring a property of the cell associated with activation of the DNA damage response pathway selected from the group consisting of cellular proliferation, cellular viability, cellular morphology, senescence associated beta-galactosidase activity, phospohorylation of p53 or p95, phosphorylation of ATM, phosphorylation of H2AX, induction of S phase arrest or induction of apoptosis, Wherein a change in the property compared to a control indicates a modulator of WRN. |