abstract |
Provided is the use of a Neisserial lipo-oligosaccharide (LOS) in the manufacture of a medicament for raising an immune response against an antigen in a mammal, whereby the Neisserial LOS is has a specified formula, and includes a lipid A moiety which is a wild-type Lipid A moiety or a Lipid A moiety with reduced toxicity and whereby the medicament is prepared for use as an adjuvant with said antigen. The antigen may be from a bacterium, virus, fungus, parasite, cancer cell or allergen. |