| abstract |
Disclosed is a receptor coupling agent comprising at least two components, wherein said agent specifically crosslinks at least two distinct TNF family receptors, and induces formation of heteromeric receptor complexes, said receptor coupling agent comprising a first binding specificity directed to a TNF receptor containing a death domain, and a second binding specificity directed to a TNF receptor containing a non-death domain, wherein the first and second binding specificities are conferred by a component selected from the group consisting of an antibody, an antigen binding fragment thereof, an scFv molecule, and a ligand to the TNF receptor. |