| abstract |
Disclosed is an isolated human monoclonal antibody or antigen binding portion thereof that specifically binds to Clostridium difficile toxin A and neutralises toxin A in vitro or in vivo. The disclosed antibody protects from or inhibits C. difficile-mediated colitis in a subject; antibiotic-associated colitis in a subject; C. difficile-mediated pseudomembranous colitis (PMC) in a subject; C. difficile-mediated diarrhea in a subject; and inhibits relapse of C. difficile-mediated disease. |