abstract |
Disclosed is an albumin fusion protein comprising two or more tandemly oriented Glucagon-Like-Peptide 1 (GLP-1) polypeptides, wherein said GLP-1 polypeptides are selected from wild-type GLP-1, functional fragments and functional variants thereof, fused to albumin or a functional fragment or functional variant thereof, wherein said albumin fragment or variant increases the serum plasma half-life of unfused GLP-1 polypeptides, and wherein said fusion protein has GLP-1 activity, and wherein the albumin fusion protein further comprises a leader sequence. |