| abstract |
Disclose is a process for the production of cyproterone acetate (M), comprising: (a) Introducing two double bonds at positions 1 and 6 of 17alpha-acetoxyprogesterone (H) to convert it into the 1,4,6-triene compound (I1) by a single step procedure; (b) Introducing a methylene group bridging positions 1 and 2 to yield the 1,2alpha-methylene compound (J1); (c) Introducing an oxido group bridging positions 6 and 7 of (J1) to yield the 6,7alpha-epoxy compound (K1); (d) Transforming the epoxy group of (K1) to the 6-chloro-7-hydroxy compound (L1); and (e) Converting (L1) to cyproterone acetate (M). |