| abstract |
Disclosed is a compound of formula (1), or a salt or hydrate thereof, wherein n is 0, 1, or 2, X1 is CH or N, R10 is a 5-10 membered cycloalkyl or cycloalkenyl, optionally substituted with a substituent from Group A1, two of R30, R31, and R32 may together form =O or -CH2-, or be separate substituents as described, R40 is C1-10alkyl optionally substituted with a substituent selected from group D1, and wherein the rest of the substituents are as described in the specification. Also disclosed is the use of the compound to treat inflammatory diseases, autoimmune diseases, inflammatory bowel disease, irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma, atopic dermatitis, ulcerative colitis or Crohn's disease. |