abstract |
Use of a compound of formula (XIII), (XIV) or (XV) or a pharmaceutically acceptable salt or ester thereof in the manufacture of a medicament for the treatment of a host infected with a flavivirus or a pestivirus is disclosed, wherein: Base is a purine or pyrimidine base; R1 and R2 are independently H; mono, di or triphosphate; acyl; alkyl; an amino acid; a carbohydrate; a peptide; or other pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R1 and R2 are independently H or phosphate; R6 is alkyl; alkenyl or alkynyl; and X is O, S, SO2 or CH2. |