| abstract |
Disclosed are derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof; wherein the substituents are defined within the specification, as well as pharmaceutical compositions comprising these compounds and uses thereof for the manufacture of a pharmaceutical composition for the prevention and/or treatment of atherosclerosis, endothelial dysfunctions, vasospasm, cardiac allograft vasculopathy, platelet activation, thrombosis, stroke, pathological conditions where oxidative stress plays a role in their pathogenesis, pathological conditions where a deficit of nitric oxide plays a role in their pathogenesis, and/or tissue damage due to ischemia and/or due to ischemiareperfusion. |