http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-545338-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate | 2004-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c79ee99565f9ce4e0f3c7c073f9c14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a0c70dd32466b232c55b736c15671c3 |
| publicationDate | 2009-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-545338-A |
| titleOfInvention | Novel method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof |
| abstract | Disclosed is a process for industrial synthesis of the compound formula (I) and its pharmaceutically acceptable salts, characterised in that a compound of formula (II) wherein R1 represents a benzyl or linear or branched (C1-C6)alkyl group, is reacted with a compound of formula (III) having the S configuration wherein X represents a halogen atom and R2 represents a protecting group for the amino function, in the presence of a base to yield after deprotection of the amino function, a compound of formula (IV) wherein R1 is as defined hereinbefore, which is reacted with ethyl 2-oxopentanoate under hydrogen pressure, in the presence of platinum-on-carbon to yield a compound of formula (V) wherein R-1 is as defined hereinbefore, which is deprotected to yield the compound of formula (I). |
| priorityDate | 2003-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.