| abstract |
Provided is a modified antisense oligonucleotide targeting eukaryotic initiation factor 4E (eIF4E), comprising a specified nucleotide sequence having at least one chemically modified sugar moiety, internucleoside linkage, or nucleobase, or a pharmaceutically acceptable salt thereof. Further provided are specific modified sugars in said oligonucleotides, pharmaceutical compositions comprising the oligonucleotides and use of the oligonucleotides for the manufacture of a medicament for the treatment of a condition or disease associated with eIF4E expression or overexpression. |