| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1fe84084eed7f266d099c2d96e0eab56 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525 |
| filingDate |
2004-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e616c6832d6f6654c2219ea023d29b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_260bf7ce3280e5a02eebb1e5d12af062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40b810d712c1533830ec40915324a551
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10e9b980f9447aa9958bc8ce79826854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac0b837d6620c429397c9fa467cef5a8 |
| publicationDate |
2008-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-543976-A |
| titleOfInvention |
Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation |
| abstract |
Disclosed is an immunogenic analogue of a human TNFalpha protein, wherein said analogue comprises an immunogenized monomeric TNFalpha polypeptide or TNFalpha di- or trimer. The analogue further comprises a toxicity reducing or abolishing mutation selected from the group consisting of Y87S, D143N or A145R, the amino acid numbering setting out from the N-terminal valine in human TNFalpha. Also disclosed is a nucleic acid fragment encoding the analogue as well as to vectors and transformed cells useful in the preparation of the analogue and methods of down-regulating TNFalpha in a subject in need thereof. |
| priorityDate |
2003-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |